Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect

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Last updated 17 julho 2024

Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect

Enhancer of Zeste Homologue 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that is critical for determining cell identi…

Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor preventing metastasis in triple-negative breast cancer cells – ScienceOpen

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer

Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer - ScienceDirect

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Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect

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Mechanisms of Polycomb group protein function in cancer

Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 'Readout', and Phase Separation-Based Compaction: Trends in Genetics

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