Cells, Free Full-Text
Por um escritor misterioso
Last updated 16 julho 2024
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Community-acquired pneumonia remains a major contributor to global communicable disease-mediated mortality. Neutrophils play a leading role in trying to contain bacterial lung infection, but they also drive detrimental pulmonary inflammation, when dysregulated. Here we aimed at understanding the role of microRNA-223 in orchestrating pulmonary inflammation during pneumococcal pneumonia. Serum microRNA-223 was measured in patients with pneumococcal pneumonia and in healthy subjects. Pulmonary inflammation in wild-type and microRNA-223-knockout mice was assessed in terms of disease course, histopathology, cellular recruitment and evaluation of inflammatory protein and gene signatures following pneumococcal infection. Low levels of serum microRNA-223 correlated with increased disease severity in pneumococcal pneumonia patients. Prolonged neutrophilic influx into the lungs and alveolar spaces was detected in pneumococci-infected microRNA-223-knockout mice, possibly accounting for aggravated histopathology and acute lung injury. Expression of microRNA-223 in wild-type mice was induced by pneumococcal infection in a time-dependent manner in whole lungs and lung neutrophils. Single-cell transcriptome analyses of murine lungs revealed a unique profile of antimicrobial and cellular maturation genes that are dysregulated in neutrophils lacking microRNA-223. Taken together, low levels of microRNA-223 in human pneumonia patient serum were associated with increased disease severity, whilst its absence provoked dysregulation of the neutrophil transcriptome in murine pneumococcal pneumonia.
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Nt Novo Cella Get File - Colaboratory
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Improving cell-free glycoprotein synthesis by characterizing and enriching native membrane vesicles
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Scheme of cell free cloning using DMF. ( A ) The full length construct
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Cancers, Free Full-Text
Full-spectrum cell-free RAN for 6G systems: s
Nature Reviews Molecular Cell Biology on X: From May cover Challenges and directions in studying cell–cell communication by #ExtracellularVesicles @DaveCarter1234 @guillaume_niel @VaderPieter Clayton Lambert & Raposo #EVsAreCool FREE pdf: https
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Antibodies, Free Full-Text
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Sequencing of Circulating Cell-free DNA during Pregnancy
The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. - Abstract - Europe PMC
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Ds Kumar Strömungsmechanik Pdf Kostenloser Download - Colaboratory
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Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system, Inflammation and Regeneration
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Anomalous Scaling of Gene Expression in Confined Cell-Free Reactions
Labile coat: reason for noninfectious cell-free varicella-zoster virus in culture. - Abstract - Europe PMC
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