Cancers, Free Full-Text

Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc protein expression. Mechanistic studies indicated that UHRF1 directly interacts with c-Myc, enabling ALL expansion via the CDK4/6-phosphoRb axis. Our findings highlight a previously unknown role of UHRF1 in regulating c-Myc protein expression and implicate UHRF1 as a potential therapeutic target in ALL.

100% Cancer Free sticker — Perch Handmade

MD Anderson Cancer Center: Cancer Treatment & Cancer Research

Kidney Cancer Text · Free Stock Photo

Cancer-Free, Third Edition by Bill Henderson - Audiobook

Community Cancer Screening - Cancer Care Services

National Comprehensive Cancer Network - Home

Cancers, Free Full-Text

Thoracic Cancer - Wiley Online Library

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical

Colorectal Cancer Awareness Month Graphics - National LGBT Cancer

10 Year Cancer Survivor Card Remission Card Cancer Free Card

from Flow Cytometry to Cytomics, Page 2

Cancer: Its Causes, Symptoms & Treatment, Giving the Results of

O Amar Mota Bou Get File - Colaboratory

Cancer